Publications

  1. Assessing apoptotic sensitivity in primary mouse B cells by BH3 profiling
    Kinz N & Riley JS
    in press

  2. Super-resolution imaging of mitochondrial DNA release
    Lochner M & Riley JS
    in press

  3. Large transient assembles of Apaf1 constitute the apoptosome in cells
    Borgeaud AC, Ganeva I, Klein C, Stooss A, Ross-Kaschitza D, Wu L, Riley JS, Tait SWG, Lemmin T, Kaufmann T & Kukulski W
    Nature Communications

  4. Caspase-2 kills cells with extra centrosomes
    Rizzotto D, Vigorito V, Rieder P, Gallob F, Moretta GM, Soratroi C, Riley JS, Bellutti F, Veli SL, Mattivi A, Lohmüller M, Herzog S, Bornhauser BC, Jacotot ED, Villunger A, Fava LL
    Science Advances

  5. Large transient assemblies of Apaf1 constitute the apoptosome in cells
    Borgeaud AC, Ganeva I, Klein C, Stoos A, Ross-Kaschitza D, Wu L, Riley JS, Tait SWG, Lemmin T, Kaufmann T, Kukulski W
    biorXiv preprint

  6. Caspase-2 kills cells with extra centrosomes
    Rizzotto D, Vigorito V, Rieder P, Gallob F, Moretta GM, Soratroi C, Riley JS, Bellutti F, Veli SL, Mattivi A, Lohmüller M, Herzog S, Bornhauser BC, Jacotot ED, Villunger A, Fava LL
    biorXiv preprint

  7. Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis
    von Mässenhausen A, Schlecht MN, Beer K, Maremonti F, Tonnus W, Belavgeni A, Gavali S, Flade K, Riley JS, Gonzalez NM, Brucker A, Becker JN, Tmava M, Meyer C, Peitzsch M, Hugo C, Gembardt F, Friedmann Angeli JPF, Bornstein SR, Tait SWG & Linkermann A
    Science Advances

  8. Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response
    Vringer E*, Heilig R*, Riley JS, Black A, Cloix C, Skalka G, Montes-Gómez AE, Aguado A, Lilla S, Walczak H, Gyrd-Hansen M, Murphy DJ, Huang DT, Zanivan S & Tait SWG
    The EMBO Journal

  9. Apoptotic stress causes mtDNA release during senescence and drives the SASP
    Victorelli S*, Salmonowicz H*, Chapman J*, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Epindola-Netto JM, Jurk D, Lagnado A, Gomez LS, Farr J, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufman SH, Zacharioudakis E, Gavathiotis E, LeBasseur N, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG & Passos JF
    Nature

  10. Mitochondrial outer membrane integrity regulates a ubiquitin-dependent NF-κB inflammatory response
    Vringer E, Riley JS, Black A, Cloix C, Lilly S, Walczak H, Gyrd-Hansen M, Huang DT, Zanivan S & Tait SWG
    biorXiv preprint

  11. When cell death goes wrong: inflammatory outcomes of failed apoptosis and mitotic cell death
    Bock FJ & Riley JS
    Cell Death & Differentiation (Review)

  12. Voices from beyond the grave: the impact of apoptosis on the microenvironment
    Riley JS & Bock FJ
    BBA Molecular Cell Research (Review)

  13. Modulating mitofusins to control mitochondrial function and signalling
    Zacharioudakis E, Agianian B, Kumar V MV, Biris N, Garner TP, Rabinovich-Nikitin I, Ouchida AT, Margulets V, Nordstrøm LU, Riley JS, Dolgalev I, Chen Y, Wittig AJH, Pekson R, Matthew C, Wei P, Tsirigos A, Tait SWG, Kirschenbaum LA, Kitsis RN & Gavathiotis E
    Nature Communications

  14. Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage
    Cao K*, Riley JS*, Heilig R, Montes-Gómez AE, Vringer E, Berthenet K, Cloix C, Elmasry Y, Spiller DG, Ichim G, Campbell KJ, Gilmore AP & Tait SWG
    Developmental Cell

  15. PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness
    Rabas N, Palmer S, Mitchell L, Ishmael S, Goelke A, Riley JS, Tait SWG, Gammage P, Macpherson I & Norman JC
    Journal of Cell Biology

  16. The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)
    Roberts JZ, Holohan C, Sessler T, Fox J, Crawford N, Riley JS, Khawaja H, Majkut J, Evergren E, Humphreys LM, Ferris J, Higgins C, Espona-Fiedler M, Moynagh P, McDade SS & Longley DB
    Cell Death & Differentiation

  17. Mitochondrial DNA in inflammation and immunity
    Riley JS & Tait SWG
    EMBO reports (Review)

  18. Mitochondria and pathogen immunity: from killer to firestarter
    Riley JS & Tait SWG
    The EMBO Journal (News & Views)

  19. Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis
    Riley JS, Quarato G, Cloix C, Lopez J, O’Prey J, Pearson M, Chapman J, Sesaki H, Carlin LM, Passos JF, Wheeler AP, Ryan KM & Tait SW
    The EMBO Journal

  20. Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells
    Villa E, Proïcs E, Rubio-Patiño C, Obba S, Zunino B, Bossowski JP, Rozier JP, Chiche J, Mondragón L, Riley JS, Marchetti S, Verhoeyen E, Tait SWG, Ricci JE
    Cell Reports

  21. Mito-priming as a method to engineer Bcl-2 addiction
    Lopez J, Bessou M*, Riley JS*, Giampazolias E, Todt F, Rochegüe T, Oberst A, Green DR, Edlich F, Ichim G & Tait SWG
    Nature Communications

  22. Mechanisms of mitophagy: putting the powerhouse into the doghouse
    Riley JS & Tait SWG
    Biological Chemistry (Review)

  23. DED or alive: assembly and regulation of the death effector domain complexes
    Riley JS, Malik A, Holohan C & Longley DB
    Cell Death & Disease (Review)

  24. Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death
    Ichim G, Lopez J, Ahmed S, Muthalagu N, Giampazolias E, Delgado ME, Haller M, Riley JS, Mason SM, Athineos D, Parsons MJ, van de Kooij B, Bouchier-Hayes L, Chalmers AJ, Rooswinkel RW, Oberst A, Blyth K, Rehm M, Murphy DJ & Tait SWG
    Molecular Cell

  25. Efficient drug delivery and induction of apoptosis in colorectal tumors using a death receptor 5-targeted nanomedicine
    Schmid D, Fay F, Small DM, Jaworski J, Riley JS, Tegazzini D, Fenning C, Jones DS, Johnston PG, Longley DB & Scott CJ
    Molecular Therapy

  26. Differential affinity of FLIP and procaspase 8 for FADD’s DED binding surfaces regulates DISC assembly
    Majkut J, Sgobba M, Holohan C, Crawford N, Logan AE, Kerr E, Redmond KL, Higgins CA, Riley JS, Stasik I, Fennell DA, Van Schaeybroeck S, Haider S, Johnston PG, Haigh D & Longley DB
    Nature Communications

  27. Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer
    Riley JS, Hutchinson R, McArt DG, Crawford N, Holohan C, Van Schaeybroeck S, Paul I, Johnston PG, Fennell DA, Gately K, O’Byrne K, Cummins R, Kay E, Hamilton P, Stasik I & Longley DB
    Cell Death & Disease

  28. Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis
    Kerr E, Holohan C, McLaughlin KM, Makjut J, Dolan S, Redmond K, Riley J, McLaughlin K, Stasik I, Crudden M, Van Schaeybroeck S, Fenning C, O’Connor R, Kiely P, Sgobba M, Haigh D, Johnston PG & Longley DB
    Cell Death & Differentiation