2024

Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis
von Mässenhausen A, Schlecht MN, Beer K, Maremonti F, Tonnus W, Belavgeni A, Gavali S, Flade K, Riley JS, Gonzalez NM, Brucker A, Becker JN, Tmava M, Meyer C, Peitzsch M, Hugo C, Gembardt F, Friedmann Angeli JPF, Bornstein SR, Tait SWG & Linkermann A
Science Advances

Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response
Vringer E*, Heilig R*, Riley JS, Black A, Cloix C, Skalka G, Montes-Gómez AE, Aguado A, Lilla S, Walczak H, Gyrd-Hansen M, Murphy DJ, Huang DT, Zanivan S & Tait SWG
The EMBO Journal

2023

Apoptotic stress causes mtDNA release during senescence and drives the SASP
Victorelli S*, Salmonowicz H*, Chapman J*, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Epindola-Netto JM, Jurk D, Lagnado A, Gomez LS, Farr J, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufman SH, Zacharioudakis E, Gavathiotis E, LeBasseur N, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG & Passos JF
Nature

Mitochondrial outer membrane integrity regulates a ubiquitin-dependent NF-κB inflammatory response
Vringer E, Riley JS, Black A, Cloix C, Lilly S, Walczak H, Gyrd-Hansen M, Huang DT, Zanivan S & Tait SWG
biorXiv preprint

When cell death goes wrong: inflammatory outcomes of failed apoptosis and mitotic cell death
Bock FJ & Riley JS
Cell Death & Differentiation (Review)

2022

Voices from beyond the grave: the impact of apoptosis on the microenvironment
Riley JS & Bock FJ
BBA Molecular Cell Research (Review)

Modulating mitofusins to control mitochondrial function and signalling
Zacharioudakis E, Agianian B, Kumar V MV, Biris N, Garner TP, Rabinovich-Nikitin I, Ouchida AT, Margulets V, Nordstrøm LU, Riley JS, Dolgalev I, Chen Y, Wittig AJH, Pekson R, Matthew C, Wei P, Tsirigos A, Tait SWG, Kirschenbaum LA, Kitsis RN & Gavathiotis E
Nature Communications

Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage
Cao K*, Riley JS*, Heilig R, Montes-Gómez AE, Vringer E, Berthenet K, Cloix C, Elmasry Y, Spiller DG, Ichim G, Campbell KJ, Gilmore AP & Tait SWG
Developmental Cell

2021

PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness
Rabas N, Palmer S, Mitchell L, Ishmael S, Goelke A, Riley JS, Tait SWG, Gammage P, Macpherson I & Norman JC
Journal of Cell Biology

2020

The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)
Roberts JZ, Holohan C, Sessler T, Fox J, Crawford N, Riley JS, Khawaja H, Majkut J, Evergren E, Humphreys LM, Ferris J, Higgins C, Espona-Fiedler M, Moynagh P, McDade SS & Longley DB
Cell Death & Differentiation

Mitochondrial DNA in inflammation and immunity
Riley JS & Tait SWG
EMBO reports (Review)

2019

Mitochondria and pathogen immunity: from killer to firestarter
Riley JS & Tait SWG
The EMBO Journal (News & Views)

2018

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis
Riley JS, Quarato G, Cloix C, Lopez J, O’Prey J, Pearson M, Chapman J, Sesaki H, Carlin LM, Passos JF, Wheeler AP, Ryan KM & Tait SW
The EMBO Journal

2017

Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells
Villa E, Proïcs E, Rubio-Patiño C, Obba S, Zunino B, Bossowski JP, Rozier JP, Chiche J, Mondragón L, Riley JS, Marchetti S, Verhoeyen E, Tait SWG, Ricci JE
Cell Reports

2016

Mito-priming as a method to engineer Bcl-2 addiction
Lopez J, Bessou M*, Riley JS*, Giampazolias E, Todt F, Rochegüe T, Oberst A, Green DR, Edlich F, Ichim G & Tait SWG
Nature Communications

Mechanisms of mitophagy: putting the powerhouse into the doghouse
Riley JS & Tait SWG
Biological Chemistry (Review)

2015

DED or alive: assembly and regulation of the death effector domain complexes
Riley JS, Malik A, Holohan C & Longley DB
Cell Death & Disease (Review)

Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death
Ichim G, Lopez J, Ahmed S, Muthalagu N, Giampazolias E, Delgado ME, Haller M, Riley JS, Mason SM, Athineos D, Parsons MJ, van de Kooij B, Bouchier-Hayes L, Chalmers AJ, Rooswinkel RW, Oberst A, Blyth K, Rehm M, Murphy DJ & Tait SWG
Molecular Cell

Pre-2015

Efficient drug delivery and induction of apoptosis in colorectal tumors using a death receptor 5-targeted nanomedicine
Schmid D, Fay F, Small DM, Jaworski J, Riley JS, Tegazzini D, Fenning C, Jones DS, Johnston PG, Longley DB & Scott CJ
Molecular Therapy

Differential affinity of FLIP and procaspase 8 for FADD’s DED binding surfaces regulates DISC assembly
Majkut J, Sgobba M, Holohan C, Crawford N, Logan AE, Kerr E, Redmond KL, Higgins CA, Riley JS, Stasik I, Fennell DA, Van Schaeybroeck S, Haider S, Johnston PG, Haigh D & Longley DB
Nature Communications

Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer
Riley JS, Hutchinson R, McArt DG, Crawford N, Holohan C, Van Schaeybroeck S, Paul I, Johnston PG, Fennell DA, Gately K, O’Byrne K, Cummins R, Kay E, Hamilton P, Stasik I & Longley DB
Cell Death & Disease

Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis
Kerr E, Holohan C, McLaughlin KM, Makjut J, Dolan S, Redmond K, Riley J, McLaughlin K, Stasik I, Crudden M, Van Schaeybroeck S, Fenning C, O’Connor R, Kiely P, Sgobba M, Haigh D, Johnston PG & Longley DB
Cell Death & Differentiation